Research Field
·Oral and maxillofacial tumors
·Oral Cancer and Precacner
·Salivary Gland Tumours
Education
Undergraduate student, from September 1971 to July 1974
Hubei Medical University School of Medical Sciences 1978 2 to 1979 1
Peking University School and Hospitomatology 1979 2 to1980 1
Oversea Study and Visit
Honors and Awards
· Hubei Provincial Science & Technology Department. The change of cell proliferation and adhesion molecular at the invasive tumor front and premalignant lesions of OSCC.Nx200419.
· Health Department of Hubei province. The relation of NF-KB to the invasiveness and angiogenesis in adenoid cysticcarcinomaof salivary gland .2004 A304B07.
· Natural Science Foundation of Hubei Province. Studies of the relationship between CXCR4, metastasis and angiogenesis in OSCC,.2006ABA259.
· Scientific and Technological Project of Wuhan City of China. The research on the localization of molecular probe at the invasive front of ACC. 200960323137
· National Nature Science Foundation of China. The molecular mechanism of EMT in the malignant translation of oral epithelium dysplasia. 81170971
· Rewarded the third prize of scientific and technological advancement award of people’s government, Hubei province. 973155-1
· Rewarded the second prize of 2015 annual outstanding achievement award of scientific research (natural science) of higher education. 2015-086(1)
Publications
1.Jiali Zhang, Bin Peng and Xinming Chen*.Expressions of nuclear factor KB,inducible nitric oxide synthase,and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: Correlations with the angiogenesis and clinical outcome. Clinical Cancer Research.Vol.11,7334-7343,oct15,2005
2.Shaodong Yang, Xinming Chen*, Li Wang, Jiali Zhang. Non-sebaceoua lymphadenoma of the salivary gland:Case report with immunohistochemical investigation.Virchows Arch (2007) 450:595-599
3.Shaodong Yang, Jiali Zhang, Xinming Chen*, Li Wang, Fusheng Xie,Clear cell carcinoma (NOS) of Salivary glands: A clinicopathologicalstudy of 4 cases and review of the literature , Oral Surg Oral Med Oral Path Oral Radiol and Endod 2008;106:712-720
4.Lu Shi*, Xinming Chen*, Li Wang, Lu zhang, Zhi Chen#.Expression of Caveolin-1 in Mucoepidermoid Careinoma of Salivary Glands: Correlation with Vascular endothelial growth factor, Microvessel Density and Clinical Outcomme.Cancer:120,1958-1963 (2007) (IF= 4.632)
5.Shaodong Yang, Xinming Chen* Calcifications in clear cell mucoepidermoid carcinomas Oral Surg Oral Med Oral Path Oral Radiol and Endod 2010;109:274-275
6.Shaodong Yang, Ming Zeng, Jiali Zhang, Xinming Chen*. Clear cell myoepithelial carcinoma of minor salivarygland: report of a case. Int. J Oral Maxillofacial Surgcons.2010;39: 297-300
6.Shaodong Yang, Lu Li, Ming Zeng, Xiaojie Zhu, Jiali Zhang, Xinming Chen*, Myoepithelial carcinoma of intraoral minor salivary glands: A clinicopathological study of 7 cases and review of the literature. Oral Surg Oral Med Oral Path Oral Radiol and Endod 2010;110:85-93
7.Shaodong Yang, Xinming Chen*. Epithelial-myoepithelial carcinoma with high grade transformation：a casereport. Int. J Oral Maxillofacial Surgcons.2012; 41:810-813.
8.Xiaojie Zhu , Jiali Zhang , Xinming Chen*, Xiaojie Feng.Comparison of Ki-67, cyclin E, and p63 in Benign and Malignant Human Pleomorphic Adenoma Oral Surg Oral Med Oral Path Oral Radiol and Endod.2012;113:667-672.
9. Shaodong Yang,Ming Zeng, Jiangli Zhang, Xinming Chen*.Mucinous myoepithelial carcinoma of the parotid gland: a case report of a new histologic variant, Int J Clin Exp Pathol. 2017;10(2): 2224-2230
10.Chuan-Xiang Zhou, Xin-Ming Chen, Tie-Jun Li*, Central Mucoepidermoid Carcinoma: A Clinicopathologic and Immunohistochemical Study of 39 Chinese Patients. American Journal of Surgical Pathology, 2012;36(1):18-26.
11.Xinhong Wang, Jiali Zhang , Mingwen Fan,Qian zhou, Hao Deng, Mohd Jamal Alsharif MJ，Xinming Chen*.The expression of E-cadherin at the invasive tumor front of oral squamous cell carcinoma: immunohistochemical and RT-PCR analysis with clinicopatholgical correlation. Oral Surg Oral Med Oral Path Oral Radiol and Endod 2009;107:547-554
12.Xu Meng，Li Wuyi，Xu uhong ,Chen Xinming* Expression of CXCR4 in oral squamous cell carcinoma:correlations with clinicopathology and pivotal role of proliferation. Journal of Oral Pathology and Medicine. 2010;39:63-68
13.Xinhong Wang,Si Chen, Xinming Chem*.Tumor related genes in histological normal margins correlating with local recurrent OSCC. Journal of Oral Pathology and Medicine.2016,45:83-88.
14.Jiali Zhang,Si Chen,Lan Yin, Xinming Chen*. Transcriptome profiles of moderate dysplasia in oral mucosa associated with malignant conversion, Int J Clin Exp Pathol. 2016;9(6):6109-6116.
15.Jiali Zhang*,Qian Cheng,Yi,Zhou, Yu Wang,Xinmini Chen*.Slug is a key mediator of hypoxia induced cadherin switch in HNSCC:C orrelations with poor prognosis.Oral Oncology 2013;48(6):515-520
16.Jiali* Zhang,Yu Wang, Xinming Chen*, Yi Zhou,Fangyan Jiang,Li Wang,Wen-Feng Zhang*.Mir-34a suppresses amphiyegulin and tumor metastatic potential of hend and neck aquamous cell carcinoma(HNSCC). Oncotarget,2015,5, 1-16.
17.Yi Zhong, Li Wang, Tiejun Li, Xinming Chen*. Calcifying epithelial odontogenic tumor showing malignanttransformation: a case report and review of literature The Chinese J of Dent Research. 2010,13(2):157-162.
18.Yanling Gong, Li Wang, Hengkun Wang, Tiejun Li , Xinming Chen*. The expression Of NF-κB, Ki-67 and MMP-9 in CCOT, DGCT and GCOC. Oral Oncology 2009; 45(6):515-520
19.Shaodong Yang, Xinming Chen*, Jiali Zhang, Qiong Fang.Solated Langerhans cell histiocytosis of the sublingual gland in an adult. Int J Clin Exp Pathol. 2015;8(10):13647-13650.
20. Ming Zeng, Changrong Chen Shaodong Yang, Xinming Chen*. SMARCB1 (INI1)-deficient sinonasalcarcinoma: a newly described entity. Int J Clin Exp Pathol. 2016;9(3):3454-3458
21.Shaodong Yang, Si Chen, Xinming Chen*, Xing Long*. Primary typical carcinoid tumor in the retromolar region with prominent squamou differentiation:a case report. Int. J Oral Maxillofacial Surgcons.2011;40:4991-994
22.Chen R，Chen S，Chen XM*，Long X*. Study of the Tidemark in Human Mandibular Condylar Cartilage.Archives of Oral Biology. 2011,56:1390-1397.
