• the function of microRNAs in regulation of OSCC invasion and metastasis

• tumor suppressor transcription factors in OSCC proliferation

• angeogenesis in adenoid cystic carcinoma

Education

• MD.-Ph.D. candidate, from July 2002 to July  2007 , Majored in Oral pathology,  in Stomatology school, Wuhan university

• Undergraduate student, from September 1997 to July 2002

Oversea Study and Visit

• Postdoctor, from December 2008 to January 2011, in oral biology department of dental school, University of California, Los Angeles, USA.

Research funding

• National Nature Science Foundation of China. Cooperative microRNA-mRNA network inhibit circadian gene RORA in OSCC malignant progress. 81572664

• National Nature Science Foundation of China. The molecular mechanism of hypoxia response initiated miR-34a in blocking of OSCC evasive resistance. 81172571

• National Nature Science Foundation of China. Co-expression of sVEGFR-1/IkBαM gene dual-inhibits the angiogenesis of salivary gland adenoid cystic carcinoma. 30801306

Honors and Awards

• The research on the biological behavior of malignant salivary gland tumor was rewarded the second prize of 2015 annual outstanding achievement award of scientific research (natural science) of higher education.

Publications

1. Wang Y, Chen J, Chen X, Jiang F, Sun Y, Pan Y, Zhang W, Zhang Jiali*. MiR-34a suppresses HNSCC growth through modulating cell cycle arrest and senescence. Neoplasma. 2017; 64(4):543-553.

1. Jiali Zhang, Si Chen, Lan Yin, Xinming Chen. Transcriptome profiles of moderate dysplasia in oral mucosa associated with malignant conversion. Int J Clin Exp Pathol 2016;9(6):6107-6116

3.  Jiali  Zhang*;  Yu  Wang;  Xinming  Chen*;  Yi  zhou;  Fangyan  Jiang; jironng  Chen;  Li  Wang;  Wen-FengZhang*.  MiR-34a  suppresses  amphiregulin  and  tumor metastatic  potential  of  head  and  neck  squamous  cell  carcinoma  (HNSCC).  Oncotarget, 2015,6(10),7454-69.

4.  Zhang, Jiali; Cheng, Qian; Zhou, Yi; Wang, Yu; Chen, Xinming. Slug is a key mediator of hypoxia induced cadherin switch in HNSCC: Correlations with poor prognosis. Oral Oncology, 49(11), pp 1043-1050, 2013/11.

5.  Xiaojie Zhu; Jiali Zhang (co-author); Xinming Chen; Xiaojie Feng. Comparison of Ki-67, cyclin E, and p63 in benign and malignant human pleomorphic adenoma.Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 113(5), pp 667-672, 2012/5/5.

6.  Yan Zhao; Jiali Zhang(co-author); Haibin Xia; Bi Zhang; Tao Jiang; Jiawei Wang; *Xinmin Chen; *Yining Wang. Stat3 is involved in the motility, metastasis and prognosis in lingual squamous cell carcinoma. Cell Biochemistry and Function, 4(30), pp 340-346, 2012/2/3.

7.  Zhang, Jiali; Peng, Bin. NF-kappa B promotes iNOS and VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro. Cell Proliferation, 42(2), pp 150-161, 2009/4.

8.  Jiali Zhang and Bin Peng. In vitro Angiogenesis and Expression of Nuclear Factor κB and VEGF in High and Low Metastasis Cell Lines of Salivary Gland Adenoid cystic carcinoma. BMC Cancer, 2007, 7(1):95-102.

9.  Jiali Zhang, Bin Peng, Xinming Chen. Expressions of Nuclear factor kB, Inducible Nitric Oxide synthase and vascular endothelial growth factor in Adenoid cystic carcinoma of salivary glands: correlations with the angiogenesis and clinical outcome. Clin Cancer Res, 2005,11, 7334- 7343.